Please use this identifier to cite or link to this item: https://hdl.handle.net/10953/3244
Title: Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry
Authors: Alcántara-Durán, Jaime
Moreno-González, David
Gilbert-López, Bienvenida
Molina-Díaz, Antonio
García-Reyes, Juan F.
Abstract: In this work, a sensitive method based on nanoflow liquid chromatography high-resolution mass spectrometry has been developed for the multiresidue determination of veterinary drugs residues in honey, veal muscle, egg and milk. Salting-out supported liquid extraction was employed as sample treatment for milk, veal muscle and egg, while a modified QuEChERS procedure was used in honey. The enhancement of sensitivity provided by the nanoflow LC system also allowed the implementation of high dilution factors as high as 100:1. For all matrices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus, the use of external standard calibration instead of matrix-matched calibration of each sample, and the subsequent increase of laboratory throughput. At spiked levels as low as 0.1 or 1 µg kg−1 before the 1:100 dilution, the obtained signals were still significantly higher than the instrumental limit of quantitation (S/N 10).
Keywords: nanoflow liquid chromatography;
mass spectrometry high resolution
veterinary drugs;
matrix effect 
Issue Date: 25-Apr-2018
Publisher: Elsevier
Appears in Collections:DQFA-Artículos

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