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https://hdl.handle.net/10953/3244
Title: | Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry |
Authors: | Alcántara-Durán, Jaime Moreno-González, David Gilbert-López, Bienvenida Molina-Díaz, Antonio García-Reyes, Juan F. |
Abstract: | In this work, a sensitive method based on nanoflow liquid chromatography high-resolution mass spectrometry has been developed for the multiresidue determination of veterinary drugs residues in honey, veal muscle, egg and milk. Salting-out supported liquid extraction was employed as sample treatment for milk, veal muscle and egg, while a modified QuEChERS procedure was used in honey. The enhancement of sensitivity provided by the nanoflow LC system also allowed the implementation of high dilution factors as high as 100:1. For all matrices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus, the use of external standard calibration instead of matrix-matched calibration of each sample, and the subsequent increase of laboratory throughput. At spiked levels as low as 0.1 or 1 µg kg−1 before the 1:100 dilution, the obtained signals were still significantly higher than the instrumental limit of quantitation (S/N 10). |
Keywords: | nanoflow liquid chromatography; mass spectrometry high resolution veterinary drugs; matrix effect |
Issue Date: | 25-Apr-2018 |
Publisher: | Elsevier |
Appears in Collections: | DQFA-Artículos |
Files in This Item:
File | Description | Size | Format | |
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Manuscript_FOODCHEM-.docx | 219,97 kB | Microsoft Word XML | View/Open |
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