Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry
dc.contributor.author | Alcántara-Durán, Jaime | |
dc.contributor.author | Moreno-González, David | |
dc.contributor.author | Gilbert-López, Bienvenida | |
dc.contributor.author | Molina-Díaz, Antonio | |
dc.contributor.author | García-Reyes, Juan F. | |
dc.date.accessioned | 2024-09-26T11:56:55Z | |
dc.date.available | 2024-09-26T11:56:55Z | |
dc.date.issued | 2018-04-25 | |
dc.description.abstract | In this work, a sensitive method based on nanoflow liquid chromatography high-resolution mass spectrometry has been developed for the multiresidue determination of veterinary drugs residues in honey, veal muscle, egg and milk. Salting-out supported liquid extraction was employed as sample treatment for milk, veal muscle and egg, while a modified QuEChERS procedure was used in honey. The enhancement of sensitivity provided by the nanoflow LC system also allowed the implementation of high dilution factors as high as 100:1. For all matrices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus, the use of external standard calibration instead of matrix-matched calibration of each sample, and the subsequent increase of laboratory throughput. At spiked levels as low as 0.1 or 1 µg kg−1 before the 1:100 dilution, the obtained signals were still significantly higher than the instrumental limit of quantitation (S/N 10). | es_ES |
dc.identifier.issn | 1873-7072 | es_ES |
dc.identifier.other | 10.1016/j.foodchem.2017.10.083 | es_ES |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0308814617317211 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10953/3244 | |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Food Chemistry Volume 245, Pages 19 – 38 | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.subject | nanoflow liquid chromatography; | es_ES |
dc.subject | mass spectrometry high resolution | es_ES |
dc.subject | veterinary drugs; | es_ES |
dc.subject | matrix effect | es_ES |
dc.title | Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es_ES |
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