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Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry

dc.contributor.authorAlcántara-Durán, Jaime
dc.contributor.authorMoreno-González, David
dc.contributor.authorGilbert-López, Bienvenida
dc.contributor.authorMolina-Díaz, Antonio
dc.contributor.authorGarcía-Reyes, Juan F.
dc.date.accessioned2024-09-26T11:56:55Z
dc.date.available2024-09-26T11:56:55Z
dc.date.issued2018-04-25
dc.description.abstractIn this work, a sensitive method based on nanoflow liquid chromatography high-resolution mass spectrometry has been developed for the multiresidue determination of veterinary drugs residues in honey, veal muscle, egg and milk. Salting-out supported liquid extraction was employed as sample treatment for milk, veal muscle and egg, while a modified QuEChERS procedure was used in honey. The enhancement of sensitivity provided by the nanoflow LC system also allowed the implementation of high dilution factors as high as 100:1. For all matrices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus, the use of external standard calibration instead of matrix-matched calibration of each sample, and the subsequent increase of laboratory throughput. At spiked levels as low as 0.1 or 1 µg kg−1 before the 1:100 dilution, the obtained signals were still significantly higher than the instrumental limit of quantitation (S/N 10).es_ES
dc.identifier.issn1873-7072es_ES
dc.identifier.other10.1016/j.foodchem.2017.10.083es_ES
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0308814617317211es_ES
dc.identifier.urihttps://hdl.handle.net/10953/3244
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.ispartofFood Chemistry Volume 245, Pages 19 – 38es_ES
dc.rightsCC0 1.0 Universal*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectnanoflow liquid chromatography;es_ES
dc.subjectmass spectrometry high resolutiones_ES
dc.subjectveterinary drugs;es_ES
dc.subjectmatrix effect es_ES
dc.titleMatrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones_ES

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