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Title: Functionalized nanostructures with application in regenerative medicine
Authors: Perán, Macarena
García, María Ángel
López Ruiz, Elena
Bustamante, Milán
Jiménez, Gema
Madeddu, Roberto
Marchal, Juan Antonio
Abstract: In the last decade, both regenerative medicine and nanotechnology have been broadly developed leading important advances in biomedical research as well as in clinical practice. The manipulation on the molecular level and the use of several functionalized nanoscaled materials has application in various fields of regenerative medicine including tissue engineering, cell therapy, diagnosis and drug and gene delivery. The themes covered in this review include nanoparticle systems for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells and biomimetic scaffolds useful for 2D and 3D tissue cell cultures, transplantation and clinical application.
Keywords: regenerative medicine; nanomaterials; scaffolds; cell therapy; stem cells; bone; cartilage; cell encapsulation; cell tracking; gene and drug delivery
Issue Date: 2012
metadata.dc.description.sponsorship: This work was supported in part by grants from the Consejería de Economía, Innovación y Ciencia (Junta de Andalucía, excellence project number CTS-6568) and the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria, FEDER funds, grant number PI10/02295).
Publisher: MPDI
Citation: Perán M, García MA, López-Ruiz E, Bustamante M, Jiménez G, Madeddu R, Marchal JA. Functionalized nanostructures with application in regenerative medicine. Int J Mol Sci. 2012;13(3):3847-86. doi: 10.3390/ijms13033847. Review.
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