The Role of Antioxidants on Wound Healing: A Review of the Current Evidence

Comino-Sanz, Inés María; López-Franco, María Dolores; Castro, Begoña; Pancorbo-Hidalgo, Pedro Luis

The Role of Antioxidants on Wound Healing: A Review of the Current Evidence

dc.contributor.author	Comino-Sanz, Inés María
dc.contributor.author	López-Franco, María Dolores
dc.contributor.author	Castro, Begoña
dc.contributor.author	Pancorbo-Hidalgo, Pedro Luis
dc.date.accessioned	2024-12-18T08:26:37Z
dc.date.available	2024-12-18T08:26:37Z
dc.date.issued	2021-08-13
dc.description	(1) Background: Reactive oxygen species (ROS) play a crucial role in the preparation of the normal wound healing response. Therefore, a correct balance between low or high levels of ROS is essential. Antioxidant dressings that regulate this balance are a target for new therapies. The purpose of this review is to identify the compounds with antioxidant properties that have been tested for wound healing and to summarize the available evidence on their effects. (2) Methods: A literature search was conducted and included any study that evaluated the effects or mechanisms of antioxidants in the healing process (in vitro, animal models or human studies). (3) Results: Seven compounds with antioxidant activity were identified (Curcumin, N-acetyl cysteine, Chitosan, Gallic Acid, Edaravone, Crocin, Safranal and Quercetin) and 46 studies reporting the effects on the healing process of these antioxidants compounds were included. (4) Conclusions: this review offers a map of the research on some of the antioxidant compounds with potential for use as wound therapies and basic research on redox balance and oxidative stress in the healing process. Curcumin, NAC, quercetin and chitosan are the antioxidant compounds that shown some initial evidence of efficacy, but more research in human is needed.	es_ES
dc.identifier.citation	Comino-Sanz, I.M.; López-Franco, M.D.; Castro, B.; Pancorbo-Hidalgo, P.L. The Role of Antioxidants onWound Healing: A Review of the Current Evidence. J. Clin. Med. 2021, 10, 3558.	es_ES
dc.identifier.issn	2077-0383	es_ES
dc.identifier.other	https://doi.org/10.3390/jcm10163558	es_ES
dc.identifier.uri	https://www.mdpi.com/2077-0383/10/16/3558	es_ES
dc.identifier.uri	https://hdl.handle.net/10953/3573
dc.language.iso	eng	es_ES
dc.publisher	MPDI	es_ES
dc.relation.ispartof	Journal of Clinical Medicine	es_ES
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 España	*
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/es/	*
dc.subject	wound healing	es_ES
dc.subject	oxidative stress	es_ES
dc.subject	antioxidant dressing	es_ES
dc.subject	reactive oxygen species	es_ES
dc.title	The Role of Antioxidants on Wound Healing: A Review of the Current Evidence	es_ES
dc.type	info:eu-repo/semantics/article	es_ES
dc.type.version	info:eu-repo/semantics/publishedVersion	es_ES