RUJA: Repositorio Institucional de Producción Científica

 

MicroRNA profiling during mouse ventricular maturation: a role for miR-27 modulating Mef2c expression

dc.contributor.authorChinchilla, Ana
dc.contributor.authorLozano-Velasco, Estefanía
dc.contributor.authorDaimi, Houria
dc.contributor.authorEsteban-Ruiz, Francisco José
dc.contributor.authorCrist, Colin
dc.contributor.authorAránega, Amelia Eva
dc.contributor.authorFranco, Diego
dc.date.accessioned2025-01-16T10:03:05Z
dc.date.available2025-01-16T10:03:05Z
dc.date.issued2010-08-24
dc.description.abstractAims: Non-coding RNA has been recently demonstrated to be a novel mechanism for modulation of gene expression at the post-transcriptional level. The importance of microRNAs in the cardiovascular system is now apparent. Mutations of distinct microRNAs have provided evidence for fundamental roles of microRNAs during cardiovascular development. However, there is limited information about global microRNA profiles during mouse heart development. In this study, we have gained insight from the expression profiles of microRNAs during mouse ventricular development by microarray and qRT-PCR analysis. Methods and results: Our microarray analysis reveals that relatively few microRNAs display either increasing or decreasing expression profiles during ventricular chamber formation. Interestingly, most of the differentially expressed microRNAs display a rather discrete peak of expression at particular developmental stages. Furthermore, we demonstrate that micro-RNA-27b (miR-27b) displays an overt myocardial expression during heart development and that the transcription factor-encoding gene Mef2c is an miR-27b target. Conclusion: Our data present a comprehensive profile of microRNA expression during ventricular maturation, providing an entry point for investigation of the functional roles of the most abundantly and differentially expressed microRNAs during cardiogenesises_ES
dc.description.sponsorshipVI EU Integrated Project ‘Heart Failure and Cardiac Repair’ LSHM-CT-2005-018630; Junta de Andalucía Proyecto de Excelencia ‘Desarrollo Cardiovascular y Terapia Celular’ CTS-1614; Ministerio de Ciencia e Innovación MICINN BFU2009-11566 y MICINN BFU2008-01217; Junta de Andalucia CTS-446 y BIO-302es_ES
dc.identifier.citationChinchilla A, Lozano E, Daimi H, Esteban FJ, Crist C, Aranega AE, Franco D. MicroRNA profiling during mouse ventricular maturation: a role for miR-27 modulating Mef2c expression. Cardiovasc Res. 2011 Jan 1;89(1):98-108. doi: 10.1093/cvr/cvq264. Epub 2010 Aug 24. PMID: 20736237.es_ES
dc.identifier.issnOnline ISSN 1755-3245 - Print ISSN 0008-6363es_ES
dc.identifier.other10.1093/cvr/cvq264es_ES
dc.identifier.urihttps://academic.oup.com/cardiovascres/article/89/1/98/325183?login=truees_ES
dc.identifier.urihttps://hdl.handle.net/10953/4010
dc.publisherOxfordes_ES
dc.relation.ispartofCardiovascular Research 2011, Vol 89, Issue 1es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectmicroRNAses_ES
dc.subjectCardiogenesises_ES
dc.subjectMicroarrayses_ES
dc.subjectMef2ces_ES
dc.subjectmiR-27bes_ES
dc.titleMicroRNA profiling during mouse ventricular maturation: a role for miR-27 modulating Mef2c expressiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES

Archivos

Bloque original

Mostrando 1 - 2 de 2
Cargando...
Miniatura
Nombre:
Chinchilla 2011 CardResc Supp.pdf
Tamaño:
370.82 KB
Formato:
Adobe Portable Document Format
Descripción:
Material Suplementario
Cargando...
Miniatura
Nombre:
Chinchilla 2011 CardResc.pdf
Tamaño:
824.9 KB
Formato:
Adobe Portable Document Format
Descripción:
Artículo original

Bloque de licencias

Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.98 KB
Formato:
Item-specific license agreed upon to submission
Descripción:

Colecciones