Expression of Elafin and CD200 as Immune Checkpoint Molecules Involved in Celiac Disease.

Abstract

This study investigates the role of immune checkpoint molecules in celiac disease (CD), focusing on the CD200/CD200R pathway and Elafin expression and their influence on immune regulation. Limited research exists on these molecules in CD, making these findings significant for understanding its clinical aspects. The results revealed elevated CD200 and CD200R levels and reduced PI3 expression in CD patients compared to healthy controls. CD200 expression, regulated by IFN-gamma, interacts with CD200R to stimulate Th1 and Th17 cytokine production. Specific SNPs, such as rs1733103 and rs41282752, were associated with CD, implicating genetic predisposition. The dysregulation of immune checkpoints in CD contributes to inflammation and autoimmunity, suggesting that therapies targeting these pathways could restore immune balance.