Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat
dc.contributor.author | Wangensteen, Rosemary | |
dc.contributor.author | Gómez-Guzmán, Manuel | |
dc.contributor.author | Banegas, Inmaculada | |
dc.contributor.author | Rodríguez-Gómez, Isabel | |
dc.contributor.author | Jiménez-Moleón, Rosario | |
dc.contributor.author | Duarte, Juan | |
dc.contributor.author | García-Estaño, Joaquín | |
dc.contributor.author | Vargas, Félix | |
dc.date.accessioned | 2024-02-11T07:47:37Z | |
dc.date.available | 2024-02-11T07:47:37Z | |
dc.date.issued | 2022-05-25 | |
dc.description.abstract | This study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings. Dose–response curves to DAA-I were compared with those to angiotensin II (Ang II). The Ang II-type-1 (AT1) receptor blocker, losartan, was used to evaluate the role of AT1 receptors in the responses to DAA-I. Studies were also conducted of the responsiveness in aortic rings after endothelium removal, nitric oxide synthase inhibition, or AT2 receptor blockade. DAA-I induced a dose-related systemic pressor response that was shifted to the right compared with Ang II. Losartan markedly attenuated the responsiveness to DAA-I. DAA-I showed a similar pattern in renal vasculature and aortic rings. In aortic rings, removal of endothelium and nitric oxide inhibition increased the sensitivity and maximal response to DAA-I and Ang II. AT2 receptor blockade did not significantly affect the responsiveness to DAA-I. According to these findings, DAA-I increases the systemic blood pressure and vascular tone in conductance and resistance vessels via AT1 receptor activation. This vasoconstrictor effect of DAA-I participates in the homeostatic control of arterial pressure, which can also contribute to the pathogenesis of hypertension. DAA-I may therefore be a potential therapeutic target in cardiovascular disease. | es_ES |
dc.identifier.other | 10.3390/biomedicines10061230 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10953/2313 | |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation.ispartof | BIOMEDICINES 10 (6)1230 | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.subject | Des-aspartate-angiotensin I | es_ES |
dc.subject | Hypertension | es_ES |
dc.subject | Kidney | es_ES |
dc.subject | Renin-angiotensin system | es_ES |
dc.subject | Vascular reactivity | es_ES |
dc.title | Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
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