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Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat

dc.contributor.authorWangensteen, Rosemary
dc.contributor.authorGómez-Guzmán, Manuel
dc.contributor.authorBanegas, Inmaculada
dc.contributor.authorRodríguez-Gómez, Isabel
dc.contributor.authorJiménez-Moleón, Rosario
dc.contributor.authorDuarte, Juan
dc.contributor.authorGarcía-Estaño, Joaquín
dc.contributor.authorVargas, Félix
dc.date.accessioned2024-02-11T07:47:37Z
dc.date.available2024-02-11T07:47:37Z
dc.date.issued2022-05-25
dc.description.abstractThis study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings. Dose–response curves to DAA-I were compared with those to angiotensin II (Ang II). The Ang II-type-1 (AT1) receptor blocker, losartan, was used to evaluate the role of AT1 receptors in the responses to DAA-I. Studies were also conducted of the responsiveness in aortic rings after endothelium removal, nitric oxide synthase inhibition, or AT2 receptor blockade. DAA-I induced a dose-related systemic pressor response that was shifted to the right compared with Ang II. Losartan markedly attenuated the responsiveness to DAA-I. DAA-I showed a similar pattern in renal vasculature and aortic rings. In aortic rings, removal of endothelium and nitric oxide inhibition increased the sensitivity and maximal response to DAA-I and Ang II. AT2 receptor blockade did not significantly affect the responsiveness to DAA-I. According to these findings, DAA-I increases the systemic blood pressure and vascular tone in conductance and resistance vessels via AT1 receptor activation. This vasoconstrictor effect of DAA-I participates in the homeostatic control of arterial pressure, which can also contribute to the pathogenesis of hypertension. DAA-I may therefore be a potential therapeutic target in cardiovascular disease.es_ES
dc.identifier.other10.3390/biomedicines10061230es_ES
dc.identifier.urihttps://hdl.handle.net/10953/2313
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.ispartofBIOMEDICINES 10 (6)1230es_ES
dc.rightsCC0 1.0 Universal*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectDes-aspartate-angiotensin Ies_ES
dc.subjectHypertensiones_ES
dc.subjectKidneyes_ES
dc.subjectRenin-angiotensin systemes_ES
dc.subjectVascular reactivityes_ES
dc.titleVasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rates_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES

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