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Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents.

dc.contributor.authorPrieto-Gómez, María Isabel
dc.contributor.authorSegarra, Ana Belén
dc.contributor.authorBanegas, Inmaculada
dc.contributor.authorMartínez-Cañamero, Magdalena
dc.contributor.authorDurán, Raquel
dc.contributor.authorVives, Francisco
dc.contributor.authorDomínguez-Vías, Germán
dc.contributor.authorRamírez-Sánchez, Manuel
dc.date.accessioned2024-07-30T10:21:08Z
dc.date.available2024-07-30T10:21:08Z
dc.date.issued2023-11-06
dc.description.abstractIt has been suggested that the neuro-visceral integration works asymmetrically and that this asymmetry is dynamic and modifiable by physio-pathological influences. Aminopeptidases of the renin-angiotensin system (angiotensinases) have been shown to be modifiable under such conditions. This article analyzes the interactions of these angiotensinases between the left or right frontal cortex (FC) and the same enzymes in the hypothalamus (HT), pituitary (PT), adrenal (AD) axis (HPA) in control spontaneously hypertensive rats (SHR), in SHR treated with a hypotensive agent in the form of captopril (an angiotensin-converting enzyme inhibitor), and in SHR treated with a hypertensive agent in the form of the L-Arginine hypertensive analogue L-NG-Nitroarginine Methyl Ester (L-NAME). In the control SHR, there were significant negative correlations between the right FC with HPA and positive correlations between the left FC and HPA. In the captopril group, the predominance of negative correlations between the right FC and HPA and positive correlations between the HPA and left FC was maintained. In the L-NAME group, a radical change in all types of interactions was observed; particularly, there was an inversion in the predominance of negative correlations between the HPA and left FC. These results indicated a better balance of neuro-visceral interactions after captopril treatment and an increase in these interactions in the hypertensive animals, especially in those treated with L-NAME.es_ES
dc.identifier.other10.3390/ijms242116007es_ES
dc.identifier.urihttps://hdl.handle.net/10953/3105
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.ispartofInternational Journal of Molecular Scienceses_ES
dc.rightsCC0 1.0 Universal*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectAdrenales_ES
dc.subjectAminopeptidaseses_ES
dc.subjectBrain asymmetryes_ES
dc.subjectFrontal cortexes_ES
dc.subjectHypertensiones_ES
dc.subjectHypothalamuses_ES
dc.subjectNeuro-endocrine asymmetryes_ES
dc.subjectNeuro-visceral integrationes_ES
dc.subjectPituitaryes_ES
dc.subjectRenin–angiotensin systemes_ES
dc.titleCorrelational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones_ES

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