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Influence of a diet enriched with virgin olive oil or butter on mouse gut microbiota and its correlation to physiological and biochemical parameters related to metabolic syndrome

dc.contributor.authorPrieto-Gómez, Maria Isabel
dc.contributor.authorHidalgo, Marina
dc.contributor.authorSegarra, Ana Belén
dc.contributor.authorMartínez-Rodríguez, Ana María
dc.contributor.authorCobo, Antonio
dc.contributor.authorRamírez-Sánchez, Manuel
dc.contributor.authorAbriouel, Hikmate
dc.contributor.authorGálvez, Antonio
dc.contributor.authorMartínez-Cañamero, Magdalena
dc.date.accessioned2025-01-27T00:05:13Z
dc.date.available2025-01-27T00:05:13Z
dc.date.issued2018-01
dc.description.abstractThe type of fat in the diet determinates the characteristics of gut microbiota, exerting a major role in the development of metabolic syndrome. We hypothesize that a diet enriched with extra virgin olive oil (EVOO) has a distinctive effect on the intestinal microbiome in comparison with an enriched butter diet (BT) and this effect is related to the physiological benefits exerted by EVOO. Swiss Webster mice were fed standard (SD) or two high fat diets enriched with EVOO or butter. Hormonal, physiological and metabolic parameters were evaluated. At the end of the feeding period, DNA was extracted from faeces and the 16S rRNA genes were pyrosequenced. Among the main significant differences found, BT triggered the highest values of systolic blood pressure, correlating positively with the percentage of Desulfovibrio sequences in faeces, which in turn showed significantly higher values in BT than in EVOO. EVOO had the lowest values of plasmatic insulin, correlating inversely with Desulfovibrio, and had the lowest plasmatic values of leptin which correlated inversely with Sutterellaceae, Marispirillum and Mucilaginibacter dageonensis, the three showing significantly higher percentages in EVOO. The lowest total cholesterol levels in plasma were detected in SD, correlating positively with Prevotella and Fusicatenibacter, both taxa with significantly greater presence in SD. These results may be indicative of a link between specific diets, certain physiological parameters and the prevalence of some taxa, supporting the possibility that in some of the proposed effects of virgin olive oil the modulation of intestinal microbiota could be involved. © 2018 Prieto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.es_ES
dc.description.sponsorshipPP2009/13/03, Excelencia_2010 AGR 6340es_ES
dc.identifier.citation13. Prieto, I., Hidalgo, M., Segarra, A. B., Martínez-Rodríguez, A. M., Cobo, A., Ramírez, M., Abriouel, H., Gálvez, A., & Martínez-Cañamero, M. (2018). Influence of a diet enriched with virgin olive oil or butter on mouse gut microbiota and its correlation to physiological and biochemical parameters related to metabolic syndrome. PLOS ONE, 13(1), e0190368. https://doi.org/10.1371/journal.pone.0190368es_ES
dc.identifier.issn19326203es_ES
dc.identifier.other10.1371/journal.pone.0190368es_ES
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190368es_ES
dc.identifier.urihttps://hdl.handle.net/10953/4403
dc.language.isoenges_ES
dc.publisherPUBLIC LIBRARY SCIENCEes_ES
dc.relation.ispartofPlos Onees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectBlood-pressure es_ES
dc.subjectBile-acid es_ES
dc.subjectObesity es_ES
dc.subjectFates_ES
dc.subjectCholesterol es_ES
dc.subjectAdiposity es_ES
dc.subjectProfileses_ES
dc.titleInfluence of a diet enriched with virgin olive oil or butter on mouse gut microbiota and its correlation to physiological and biochemical parameters related to metabolic syndromees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES

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