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Comparative proteomic study of early hypoxic response in the cerebral cortex of rats submitted to two different hypoxic models

dc.contributor.authorOvelleiro, David
dc.contributor.authorBlanco-Ruiz, Santos
dc.contributor.authorHernández-Cobo, Raquel
dc.contributor.authorPeinado-Herreros, María Ángeles
dc.date.accessioned2024-01-31T23:12:45Z
dc.date.available2024-01-31T23:12:45Z
dc.date.issued2017
dc.description.abstractPurpose: The present study analyses and compares the cortical brain proteomic profiles of two different models of cerebral hypoxic insult in rats (HH: hypobaric hypoxia and HHI: ischemia followed by hypobaric hypoxia) in an attempt to describe the alterations of the early molecular hypoxic adaptive response underlying each one. Experimental Design: A quantitative proteomic profile of left-brain cortices of rats under HH, HHI, and control conditions was determined using isobaric labeling (Tandem Mass TagTM) on the protein extracts from pools of five individuals. Data are available via ProteomeXchange with identifier PXD004091. Results: Altogether, 339 proteins were confidently quantified, 99 of them showing significant variations in the hypoxic conditions with respect to the control. The HHI model presents a global effect of protein downregulation while HH produces an overall increase of the protein levels. While HH mainly affecting oxidative and energetic metabolism, HHI also interferes with synaptic transmission, neurotransmitter secretion, substantia nigra development, and triggers apoptosis through mitochondrial pathway. Conclusions and Clinical Relevance: The findings obtained show an overview of protein alterations under two hypoxic models of different aetiology and provide a basis for more detailed studies in order to unravel new specific mechanisms and therapies for hypoxic pathologies.
dc.identifier.issn1862-8346es_ES
dc.identifier.otherhttps://doi.org/10.1002/prca.201700058es_ES
dc.identifier.urihttps://hdl.handle.net/10953/1821
dc.language.isoenges_ES
dc.publisherWiley - V C H Verlag GmbHes_ES
dc.relation.ispartofProteom. Clin. Appl. [2017];[11]es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectHypoxiaes_ES
dc.subjectIschemiaes_ES
dc.subjectProteomicses_ES
dc.subjectTMTes_ES
dc.titleComparative proteomic study of early hypoxic response in the cerebral cortex of rats submitted to two different hypoxic modelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES

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