Ketamine retards recovery from reward downshift and supports conditioned taste aversion
dc.contributor.author | Agüera, Antonio | |
dc.contributor.author | Cándido, Clara | |
dc.contributor.author | Donaire, Rocío | |
dc.contributor.author | Papini, Mauricio R. | |
dc.contributor.author | Torres-Bares, Carmen | |
dc.date.accessioned | 2025-01-28T22:50:57Z | |
dc.date.available | 2025-01-28T22:50:57Z | |
dc.date.issued | 2023-12-01 | |
dc.description.abstract | Ketamine is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist with antidepressant, anxiolytic, and memory effects in clinical and preclinical studies. The present studies investigated the behavioral effects of ketamine in animals exposed to a consummatory successive negative contrast (cSNC) task involving unexpected reward downshift, negative emotion (frustration), and aversive memory. Food-restricted male rats had 5-min access to 32 % sucrose in each of 10 preshift sessions followed by 4 % sucrose in 4 postshift sessions. Unshifted controls had access to 4 % sucrose during all 14 sessions. Ketamine (10 mg/kg, ip) was injected 30 min before sessions 11 and 12 (Experiment 1) or immediately after session 11 (Experiment 3). The results showed that both pre- and postdownshift session injection of ketamine increased consummatory suppression, as Group 32-4/Ket exhibited lower sucrose intake than Groups 32-4/Sal, 4-4/Ket, and 4-4/Sal. These effects extended beyond the day(s) of injection. Experiments 2 and 4 showed that the same dose, route of administration, and time of injection induced significant conditioned taste aversion to 4 % sucrose, in the absence of reward downshift. These data suggest that ketamine induces an aversive state that may summate with frustration induced by reward downshift in the cSNC task and also support a conditioned taste aversion to 4 % sucrose in the absence of reward downshift. Implications for these and other experiments involving pre- and postsession administration of ketamine are discussed. | es_ES |
dc.description.sponsorship | The research reported in this paper was supported by the Spanish Ministry of Economy and Competitiveness (grant numbers PSI2017-87340-P and PID2021-123338NB-I00 to CT and ADRA), Junta de Andalucía (HUM-642), and University of Jaén (SCAI). Animals were maintained according to the EU Directive 2010/63/EU and Spanish Law (6/2013; R.D.53/2013) for animal experiments. Experimental procedures were approved by the institutional animal care and use committee. The authors thank D. García Tristell for her assistance with behavioral testing in Experiment 1. Corresponding author: C. Torres. | es_ES |
dc.identifier.citation | Agüera, A.D.R. ;Cándido, C., Donaire, R., Papini, M.R., & Torres, C. (2023). Ketamine retards recovery from reward downshift and supports conditioned taste aversion. Pharmacology Biochemistry and Behavior, 233: 173671 | es_ES |
dc.identifier.issn | 1873-5177 | es_ES |
dc.identifier.other | https://doi.org/10.1016/j.pbb.2023.173671 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10953/4490 | |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier Inc. | es_ES |
dc.relation.ispartof | Pharmacology Biochemistry and Behavior 2023; 233:173671 | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.subject | Reward downshift | es_ES |
dc.subject | Conditioned taste aversion | |
dc.subject | Ketamine | |
dc.subject | Frustration | |
dc.subject | Memory | |
dc.subject | Motivational summation | |
dc.subject.udc | 159.953 | es_ES |
dc.subject.udc | 159.938.36 | |
dc.subject.udc | 392.85 | |
dc.title | Ketamine retards recovery from reward downshift and supports conditioned taste aversion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
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