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New Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin

dc.contributor.authorBlanco-Ruiz, Santos
dc.contributor.authorMartínez-Lara, Esther
dc.contributor.authorSiles, Eva
dc.contributor.authorPeinado-Herreros, María Ángeles
dc.date.accessioned2024-01-29T08:40:54Z
dc.date.available2024-01-29T08:40:54Z
dc.date.issued2022
dc.description.abstractStroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke after increasing its basal levels. Therefore, its systemic administration appears to be an efficient therapy applicable to stroke and other neurodegenerative pathologies. Unfortunately, Ngb cannot cross the blood-brain barrier (BBB), making its direct pharmacological use unfeasible. Thus, the association of Ngb with a drug delivery system (DDS), such as nanoparticles (NPs), appears to be a good strategy for overcoming this handicap. NPs are a type of DDS which efficiently transport Ngb and increase its bioavailability in the infarcted area. Hence, we previously built hyaluronate NPS linked to Ngb (Ngb-NPs) as a therapeutic tool against stroke. This nanoformulation induced an improvement of the cerebral infarct prognosis. However, this innovative therapy is still in development, and a more in-depth study focusing on its long-lasting neuroprotectant and neuroregenerative capabilities is needed. In short, this review aims to update the state-of-the-art of stroke therapies based on Ngb, paying special attention to the use of nanotechnological drug-delivering tools.
dc.identifier.issn1999-4923es_ES
dc.identifier.otherhttps://doi.org/10.3390/pharmaceutics14081737es_ES
dc.identifier.urihttps://hdl.handle.net/10953/1699
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.ispartofPharmaceutics [2022];[14]:[1737]es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectStroke
dc.subjectNeuroglobin
dc.subjectNanoformulation
dc.subjectIschemia
dc.titleNew Strategies for Stroke Therapy: Nanoencapsulated Neuroglobines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES

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