Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition
Archivos
Fecha
2019-12
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Editor
MDPI
Resumen
Gluten proteins in wheat are essential for bread-making but are also responsible for triggering gastrointestinal disorders such as celiac disease (CD), which affects approximately 1% of the Western population. Currently, the only effective treatment is a strict gluten-free diet. This study explores the use of RNA interference (RNAi) to reduce the expression of genes encoding immunogenic gluten proteins, offering a potential solution for developing CD-compatible cereals. These findings highlight the potential of RNAi technology to produce wheat varieties that are less immunogenic for CD patients while retaining some functional properties.
Descripción
En pro de mi compromiso con la difusión de la ciencia, este artículo se encuentra depositado, siguiendo las normas establecidas por la editorial de la revista, en el repositorio de la Universidad de Jaén (RUJA) con su identificador persistente
Palabras clave
PBMCs, RNAi, Celiac disease, low-gluten wheat
Citación
Sánchez-León S, Giménez MJ, Comino I, et al. Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition. Nutrients. 2019;11(12):2933