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Are patients with fibromyalgia in a prothrombotic state?

dc.contributor.authorMolina-Ortega, Francisco Javier
dc.contributor.authordel-Moral, María Luisa
dc.contributor.authorla-Rubia, Mercedes
dc.contributor.authorBlanco-Ruiz, Santos
dc.contributor.authorCarmona-Martos, Ramón
dc.contributor.authorRus-Martínez, Alma
dc.date.accessioned2024-02-08T08:10:01Z
dc.date.available2024-02-08T08:10:01Z
dc.date.issued2019
dc.description.abstractObjectives: The aim of this study was to investigate thrombosis-related parameters (blood coagulation parameters, platelet indices, red blood cell [RBC] count, and inflammatory markers) in patients with fibromyalgia (FM). Method: We carried out a case–control study with 35 women with FM and 12 age-matched healthy volunteers to analyze fibrinogen levels, prothrombin time, cephaline time, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), RBC count, neutrophil-tolymphocyte ratio, and platelet-to-lymphocyte ratio (PLR). Results: The results showed significantly increased fibrinogen levels (p < .05), platelet count (p < .05), PDW (p ¼ .059), RBC count (p < .05), and PLR (p < .05) in women with FM versus the healthy volunteers. Prothrombin time (p < .05) and MPV (p < .05) were significantly lower in patients with FM than in the controls. Conclusions: Elevated platelet and RBC counts, PDW values, and fibrinogen levels as well as decreased prothrombin time are all indicative of a prothrombotic state in FM patients, which may be enhanced by an increased inflammatory tone. This prothrombotic state may increase the risk of thrombosis-related cardiovascular disease in patients with FM.
dc.identifier.issn1099-8004es_ES
dc.identifier.otherhttps://doi.org/10.1177/1099800418824716es_ES
dc.identifier.urihttps://hdl.handle.net/10953/2228
dc.language.isoenges_ES
dc.publisherSage Publications Inces_ES
dc.relation.ispartofBiol. Res. Nurs. [2019];[21]:[224-230]es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectFibrinogenes_ES
dc.subjectFibromyalgiaes_ES
dc.subjectInflammationes_ES
dc.subjectPlateletses_ES
dc.subjectProthrombines_ES
dc.titleAre patients with fibromyalgia in a prothrombotic state?es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones_ES

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