Are patients with fibromyalgia in a prothrombotic state?
dc.contributor.author | Molina-Ortega, Francisco Javier | |
dc.contributor.author | del-Moral, María Luisa | |
dc.contributor.author | la-Rubia, Mercedes | |
dc.contributor.author | Blanco-Ruiz, Santos | |
dc.contributor.author | Carmona-Martos, Ramón | |
dc.contributor.author | Rus-Martínez, Alma | |
dc.date.accessioned | 2024-02-08T08:10:01Z | |
dc.date.available | 2024-02-08T08:10:01Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Objectives: The aim of this study was to investigate thrombosis-related parameters (blood coagulation parameters, platelet indices, red blood cell [RBC] count, and inflammatory markers) in patients with fibromyalgia (FM). Method: We carried out a case–control study with 35 women with FM and 12 age-matched healthy volunteers to analyze fibrinogen levels, prothrombin time, cephaline time, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), RBC count, neutrophil-tolymphocyte ratio, and platelet-to-lymphocyte ratio (PLR). Results: The results showed significantly increased fibrinogen levels (p < .05), platelet count (p < .05), PDW (p ¼ .059), RBC count (p < .05), and PLR (p < .05) in women with FM versus the healthy volunteers. Prothrombin time (p < .05) and MPV (p < .05) were significantly lower in patients with FM than in the controls. Conclusions: Elevated platelet and RBC counts, PDW values, and fibrinogen levels as well as decreased prothrombin time are all indicative of a prothrombotic state in FM patients, which may be enhanced by an increased inflammatory tone. This prothrombotic state may increase the risk of thrombosis-related cardiovascular disease in patients with FM. | |
dc.identifier.issn | 1099-8004 | es_ES |
dc.identifier.other | https://doi.org/10.1177/1099800418824716 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10953/2228 | |
dc.language.iso | eng | es_ES |
dc.publisher | Sage Publications Inc | es_ES |
dc.relation.ispartof | Biol. Res. Nurs. [2019];[21]:[224-230] | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Fibrinogen | es_ES |
dc.subject | Fibromyalgia | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Platelets | es_ES |
dc.subject | Prothrombin | es_ES |
dc.title | Are patients with fibromyalgia in a prothrombotic state? | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es_ES |
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