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https://hdl.handle.net/10953/3228
Title: | Ambient Diode Laser Desorption Dielectric Barrier Discharge Ionization Mass Spectrometry of Nonvolatile Chemicals |
Authors: | Gilbert-López, Bienvenida Schilling, Michael Alhmann, Norman Michels, Antje Hayen, Heiko Molina-Díaz, Antonio García-Reyes, Juan F. Franzke, Joachim |
Abstract: | In this work, the combined use of desorption by a continuous wave near-infrared diode laser and ionization by a dielectric barrier discharge-based probe (laser desorption dielectric barrier discharge ionization mass spectrometry (LD-DBDI-MS)) is presented as an ambient ionization method for the mass spectrometric detection of nonvolatile chemicals on surfaces. A separation of desorption and ionization processes could be verified. The use of the diode laser is motivated by its low cost, ease of use, and small size. To achieve an efficient desorption, the glass substrates are coated at the back side with a black point (target point, where the sample is deposited) in order to absorb the energy offered by the diode laser radiation. Subsequent ionization is accomplished by a helium plasmajet generated in the dielectric barrier discharge source. Examples on the application of this approach are shown in both positive and negative ionization modes. A wide variety of multiclass species with low vapor pressure were tested including pesticides, pharmaceuticals and explosives (reserpine, roxithromycin, propazine, prochloraz, spinosad, ampicillin, dicloxacillin, enrofloxacin, tetracycline, oxytetracycline, erythromycin, spinosad, cyclo-1,3,5,7-tetramethylene tetranitrate (HMX), and cyclo-1,3,5-trimethylene trinitramine (RDX)). A comparative evaluation revealed that the use of the laser is advantageous, compared to just heating the substrate surface. |
Issue Date: | 19-Feb-2013 |
metadata.dc.description.sponsorship: | The financial support by the “Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen” and by the “Bundesministerium für Bildung und Forschung” is gratefully acknowledged. The authors also acknowledge funding support from Regional Government of Andalusia (Spain) “Junta de Andalucía” (Project Ref. P07-FQM-2614 and AGR-6066) and the Spanish “Ministerio de Economía y Competitividad” (No. CTQ-2012-34297). B.G.-L. also acknowledges a scholarship from the German Academic Exchange Service (Postdoctoral Leibniz-DAAD program (PKZ: A/11/94543)). |
Publisher: | ACS Publications |
Appears in Collections: | DQFA-Artículos |
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