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Simultaneous Testing of Multiclass Organic Contaminants in 4 Food and Environment by Liquid Chromatography/ Dielectric 5 Barrier Discharge Ionization- Mass Spectrometry

dc.contributor.authorGilbert-López, Bienvenida
dc.contributor.authorGarcía-Reyes, Juan Francisco
dc.contributor.authorMeyer, Cordula
dc.contributor.authorMichels, Antje
dc.contributor.authorFranzke, Joachim
dc.contributor.authorMolina-Díaz, Antonio
dc.contributor.authorHayen, Heiko
dc.date.accessioned2025-02-02T15:31:02Z
dc.date.available2025-02-02T15:31:02Z
dc.date.issued2012
dc.description.abstractA Dielectric Barrier Discharge Ionization (DBDI) LC/MS interface is based on the use of a lowtemperature helium plasma, which features the possibility of simultaneous ionization of species with a wide variety of physicochemical properties. In this work, the performance of LC/DBDI-MS for trace analysis of highly relevant species in food and environment has been examined. Over 75 relevant species including multiclass priority organic contaminants and residues such as pesticides, polycyclic aromatic hydrocarbons, organochlorine species, pharmaceuticals, personal care products, and drugs of abuse were tested. LC/DBDI-MS performance for this application was assessed and compared with standard LC/MS sources (electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI)). The used benchtop Orbitrap mass spectrometer features a 10 Hz polarity switching mode, so that both positive and negative ion mode acquisitions are possible with acquisition cycles matching the requirements of fast liquid chromatography. Both polar and nonpolar species (including those typically analyzed by GC/electron ionization-MS) can be tested in a single run using polarity switching mode. The methodology was found to be effective in detecting a wide array of organic compounds at concentration levels in the low ng L-1 to mg kg-1 range in wastewater and food matrices, respectively. The linearity was evaluated in an olive oil extract, obtaining good correlation coefficients in the studied range. Additionally, minor matrix effects (<=15% of signal suppression or enhancement) were observed for most of the studied analytes in this complex fatty matrix. The results obtained were compared with data from both ESI and APCI sources, obtaining a merged coverage between ESI and APCI in terms of analyte ionization and higher overall sensitivity for the proposed ion source based on the DBD principle. The use of this approach further extends the coverage of current LC/MS methods towards an even larger variety of chemical species including both polar and nonpolar (non-ESI amenable) species and may find several applications in fields such as food and environment testing or metabolomics where GC/MS and LC/MS are combined to cover as many different species as possible.es_ES
dc.description.sponsorship‘‘Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen’’ ; ‘‘Bundesministerium für Bildung und Forschung’’; Junta de Andalucía’ (Research Group FQM-323 and Project ref. AGR-6182); Ministerio de Ciencia e Innovación (Projects CONSOLIDER TRAGUA [CSD2006-00044], CTQ-2009-10897 and CTQ-2012-34297); German Academic Exchange Service (Postdoctoral Leibniz-DAAD program, PKZ: A/11/94543). Thermo Fisher Scientific (Bremen, Germany), in particular Olaf Scheibner, Martin Zeller and Thomas Möhring, for access to the Exactive.es_ES
dc.identifier.citationAnalyst 2012;137:5403-5410es_ES
dc.identifier.issn1364-5528es_ES
dc.identifier.other10.1039/c2an35705des_ES
dc.identifier.uridoi.org/10.1039/c2an35705des_ES
dc.identifier.urihttps://hdl.handle.net/10953/4612
dc.language.isoenges_ES
dc.publisherRSCes_ES
dc.relation.ispartofAnalystes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectdielectric barrier dischargees_ES
dc.subjectatmospheric pressure ionizationes_ES
dc.subjectmass spectrometryes_ES
dc.subjectliquid chromatographyes_ES
dc.subjectpesticidees_ES
dc.subjectenvironmentales_ES
dc.subjectfoodes_ES
dc.titleSimultaneous Testing of Multiclass Organic Contaminants in 4 Food and Environment by Liquid Chromatography/ Dielectric 5 Barrier Discharge Ionization- Mass Spectrometryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones_ES

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