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Grapevine shoot extract rich in trans-resveratrol and trans-ε-viniferin: evaluation of their potential use for cardiac health

dc.contributor.authorContreras Gámez, María del Mar
dc.contributor.authorFeriani , Anouar
dc.contributor.authorGómez-Cruz , Irene
dc.contributor.authorHfaiedh, Najla
dc.contributor.authorHarrath, Abdel Halim
dc.contributor.authorRomero, Inmaculada
dc.contributor.authorCastro , Eulogio
dc.contributor.authorTlili, Nizar
dc.date.accessioned2025-02-12T11:02:47Z
dc.date.available2025-02-12T11:02:47Z
dc.date.issued2023-12-02
dc.description.abstractA grapevine shoot extract (GSE) was obtained using ultrasound-assisted extraction and characterized. The main phenolic constituents were identified as stilbenoids. Among them, trans-resveratrol and trans-ε-viniferin stood out. The GSE was administered to an isoproterenol-induced myocardial injury animal model. The extract alleviated the associated symptoms of the administration of the drug, i.e., the plasma lipid profile was improved, while the disturbed plasma ion concentration, the cardiac dysfunction markers, the DNA laddering, and the necrosis of myocardial tissue were diminished. This effect could be related to the anti-oxidative potential of GSE associated with its antioxidant properties, the increased levels of endogenous antioxidants (glutathione and enzymatic antioxidants), and the diminished lipid peroxidative markers in the heart. The results also revealed angiotensin-converting enzyme (ACE)-inhibitory activity, which indicated the potential of GSE to deal with cardiovascular disease events. This work suggests that not only trans-resveratrol has a protective role in heart function but also GSE containing this biomolecule and derivatives. Therefore, GSE has the potential to be utilized in the creation of innovative functional ingredients.
dc.description.sponsorshipThe Ministry of Science and Innovation (MCIN) of Spain for the Ramón y Cajal grant (RYC2020-030546-I/AEI/10.13039/501100011033) and the European Social Fund. The “Programme of Requalification of the Spanish University System” 2021–2023—Margarita Salas. Support from the grant PID2020-112594RB-C31 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” and “Researchers Supporting Project (RSP2023R17) at King Saud University” is also acknowledged.
dc.identifier.citationContreras MdM, Feriani A, Gómez-Cruz I, Hfaiedh N, Harrath AH, Romero I, Castro E, Tlili N. Grapevine Shoot Extract Rich in Trans-Resveratrol and Trans-ε-Viniferin: Evaluation of Their Potential Use for Cardiac Health. Foods. 2023; 12(23):4351. https://doi.org/10.3390/foods12234351
dc.identifier.issn2304-8158
dc.identifier.other10.3390/foods12234351
dc.identifier.urihttps://doi.org/10.3390/foods12234351
dc.identifier.urihttps://hdl.handle.net/10953/4671
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofFoods [2023]; [12(23)]:[4351]
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spainen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectTECHNOLOGY::Chemical engineering
dc.titleGrapevine shoot extract rich in trans-resveratrol and trans-ε-viniferin: evaluation of their potential use for cardiac health
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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