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Molecularly imprinted polymer as in-line concentrator in capillary electrophoresis coupled with mass spectrometry for the determination of quinolones in bovine milk samples

dc.contributor.authorMoreno-González, David
dc.contributor.authorLara, Francisco J.
dc.contributor.authorGámiz-Gracia, Laura
dc.contributor.authorGarcía-Campaña, Ana M.
dc.date.accessioned2025-01-22T09:00:10Z
dc.date.available2025-01-22T09:00:10Z
dc.date.issued2014-09
dc.description.abstractIn this work molecularly imprinted polymers have been evaluated as sorbent for the construction of an in-line solid phase extraction analyte concentrator in capillary electrophoresis coupled with mass spectrometry for the determination of the eight regulated veterinary quinolones in bovine milk samples. Different parameters affecting the analyte concentrator performance, such as sample pH, volume and composition of the elution plug and injection time, were studied. Sample volumes of 22 μL (2 bar for 15 min) were loaded on the MISPE microcartridge and the retained analytes were eluted by injecting a plug of MeOH/H2O/NH3 (60/37/3 by volume) for 125 s at 50 mbar (60 nL). The proposed method is simple for the monitoring of these antibiotic residues in milk samples, allowing the direct injection of the samples with minimum sample pretreatment, achieving limits of detection between 3.8 and 4.7 μg kg−1 and unequivocal identification of the compounds working in tandem mass spectrometry. Recoveries ranging from 70.0 to 102.3% were obtained and satisfactory intra-day and inter-day RSDs were achieved (≤12% and 15% respectively). Reproducibility among different constructed analyte concentrators showed RSD ≤ 11%es_ES
dc.identifier.other10.1016/j.chroma.2014.07.049es_ES
dc.identifier.urihttps://hdl.handle.net/10953/4250
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsCC0 1.0 Universal*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectQuinoloneses_ES
dc.subjectBovine milk sampleses_ES
dc.subjectCapillary electrophoresises_ES
dc.subjectMolecularly imprinted polymerses_ES
dc.subjectIn-line concentratores_ES
dc.titleMolecularly imprinted polymer as in-line concentrator in capillary electrophoresis coupled with mass spectrometry for the determination of quinolones in bovine milk sampleses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.type.versioninfo:eu-repo/semantics/draftes_ES

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