Examinando por Autor "Perez-Llano, Yordanis"
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Ítem First demonstration that ascomycetous halophilic fungi (Aspergillus sydowii and Aspergillus destruens) are useful in xenobiotic mycoremediation under high salinity conditions(Elsevier, 2019-02-02) Perez-Llano, YordanisÍtem Haloadaptative responses of Aspergillus sydowii to extreme water deprivation: morphology, compatible solutes, and oxidative stress at NaCl saturation(MDPI, 2020-11) Perez-Llano, YordanisÍtem Laccases from Extremophiles(Springer, 2020) Perez-Llano, YordanisÍtem Metagenomic tools for taxonomic and functional annotation(Taylor & Francis, 2021) Perez-Llano, YordanisÍtem Omics Approaches: Impact on Bioremediation Techniques(Springer, 2018) Perez-Llano, YordanisÍtem Osmolyte Signatures for the Protection of Aspergillus sydowii Cells under Halophilic Conditions and Osmotic Shock(MDPI, 2021) Perez-Llano, YordanisÍtem Safety of a proteoliposome from Neisseria meningitides as adjuvant for a house dust mite allergy vaccine(Taylor & Francis, 2017-07-12) Perez-Llano, YordanisThe proteoliposome (PL) of Neisseria meningitidis serogroup B has been reported as a safe and potent vaccine adjuvant, inducing a TH1-skewed response. The present study describes a pre-clinical safety evaluation of an allergy therapeutic vaccine candidate based on purified allergens from Dermatophagoides siboney house dust mite and PL as adjuvant, both components adsorbed onto aluminum hydroxide gel. Two separate studies of acute toxicity evaluation were performed in mice and rabbits, and two repeatdose studies were conducted in non-sensitized and allergen-sensitized Balb/c mice, respectively. The study in sensitized mice intends to model a therapeutic setting. Aerosolized allergen challenge was used in both settings to model natural respiratory exposure. In the therapeutic setting, mice were administered with three doses containing 2 lg allergen at weekly intervals [subcutaneous route] and subsequently challenged with aerosolized allergen for 6 consecutive days. Parameters of general toxicity effects were assessed via measures of behavior, body weight, food and water consumption, and macroscopic evaluation of organs. Histological examination of organs and the injection site was performed. Potential immunotoxicity effects at the systemic level were assessed by blood eosinophil counting and serum allergen specific IgE by ELISA The vaccine did not produce general or functional toxic effects of significance, at a dose up to 100 lg allergen per kg body weight. An expected local reaction at the injection site was observed, which could be attributed mostly to the immunological effect of aluminum hydroxide. The models implemented here suggest an acceptable safety profile of this vaccine for testing in clinical trials of allergy immunotherapy.Ítem Schizophyllum commune: An unexploited source for lignocellulose degrading enzymes(Wiley, 2018) Perez-Llano, YordanisÍtem Stress reshapes the physiological response of halophile fungi to salinity(MDPI, 2020-02) Perez-Llano, YordanisÍtem Transcriptomic analysis of polyaromatic hydrocarbon degradation by the halophilic fungus Aspergillus sydowii at hypersaline conditions(John Wiley & Sons Ltd, 2021) Perez-Llano, Yordanis