Examinando por Autor "Palomeque, Teresa"
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Ítem A Comparative Analysis of Mitogenomes in Species of the Tapinoma nigerrimum Complex and Other Species of the Genus Tapinoma (Formicidae, Dolichoderinae)(MDPI, 2024-12-02) Ruiz-Mena, Areli; Mora, Pablo; Rico-Porras, José M.; Kaufmann, Bernard; Seifert, Bernhard; Palomeque, Teresa; Lorite, PedroUsing next-generation sequencing data, the complete mitogenomes of six species from the genus Tapinoma were assembled. This study explores the mitochondrial genomes of Tapinoma species, among them the five species from the Tapinoma nigerrimum complex, comparing them with each other and with other species from Dolichoderinae subfamily to understand their evolutionary relationships and evolution. Tapinoma mitochondrial genomes contain the typical set of 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNAs, and the A + T-rich control region. A phylogenetic analysis using the protein-coding gene sequences from available Dolichoderinae mitogenomes supports the monophyletic nature of the genus Tapinoma, with the T. nigerrimum complex forming a well-supported clade. Key findings include genetic traits unique to the T. nigerrimum complex, such as a start codon in the atp8 gene and a complete stop codon in cox1, distinguishing them from other Tapinoma species. Additionally, a gene rearrangement involving tRNA-Trp, tRNA-Cys, and tRNA-Tyr was found exclusively in the Tapinoma species, suggesting a potential phylogenetic marker for the genus.Ítem Complex Evolutionary Histor of Mboumar, a Mariner Element Widely Represented in Ant Genomes(Nature Research, 2020-02) Sanllorente, Olivia; Vela, Jesús; Mora, Pablo; Ruiz-Mena, Areli; Torres, María Isabel; Lorite, Pedro; Palomeque, TeresaThis study examines the mariner-like transposable element Mboumar, previously identified in the ant Messor bouvieri, across 22 ant species from nine subfamilies, including both primitive and derived lineages. The widespread presence of Mboumar-like elements in ant genomes is evident, but the phylogenetic relationships of these elements do not align with the evolutionary history of their ant hosts. Genetic analysis revealed conserved transposable elements with uninterrupted open reading frames in 11 species, encoding transposases closely resembling the active Mboumar-9 transposase. Selection tests indicate purifying selection has shaped the evolution of these elements.Ítem Dysregulation of the PD-1/PD-L1 pathway contributes to the pathogenesis of celiac disease(Nature group, 2019-06) Ponce de León, Candelaria; López-Casado, Miguel Ángel; Lorite, Pedro; Palomeque, Teresa; Torres, María IsabelThis study investigates changes in the programmed cell death 1 (PD-1)/PD-L1 pathway in celiac disease (CD), emphasizing its role in immune response regulation and its potential to enhance understanding of CD autoimmunity. The research highlights the importance of measuring PD-1 and PD-L1 levels in serum and intestinal biopsies of CD patients to explore potential links between these markers, autoimmune activity, inflammation, and disease progression.Ítem Expression of Elafin and CD200 as Immune Checkpoint Molecules Involved in Celiac Disease.(MDPI, 2024-01) Ponce de León, Candelaria; Lorite, Pedro; López-Casado, Miguel Ángel; Mora, Pablo; Palomeque, Teresa; Torres, María IsabelThis study investigates the role of immune checkpoint molecules in celiac disease (CD), focusing on the CD200/CD200R pathway and Elafin expression and their influence on immune regulation. Limited research exists on these molecules in CD, making these findings significant for understanding its clinical aspects. The results revealed elevated CD200 and CD200R levels and reduced PI3 expression in CD patients compared to healthy controls. CD200 expression, regulated by IFN-gamma, interacts with CD200R to stimulate Th1 and Th17 cytokine production. Specific SNPs, such as rs1733103 and rs41282752, were associated with CD, implicating genetic predisposition. The dysregulation of immune checkpoints in CD contributes to inflammation and autoimmunity, suggesting that therapies targeting these pathways could restore immune balance.Ítem Extracellular Vesicles: Advanced Tools for Disease Diagnosis, Monitoring, and Therapies(MDPI, 2024-12) Lorite, Pedro; Domínguez, Jorge Nicolas; Palomeque, Teresa; Torres, María IsabelExtracellular vesicles (EVs) are membrane-bound structures released by cells into their surrounding environment, facilitating intercellular communication through the transfer of proteins, lipids, and nucleic acids. These vesicles can be found in various body fluids, including blood, urine, saliva, and breast milk, between others. Due to their complexity, standardized methodologies are essential for isolating EVs with consistency and purity, enabling their application in diagnostics, therapy, and research. These EVs hold significant promise in advancing disease diagnosis and treatment, particularly in personalized and precision medicine. This review provides an updated overview of EVs, focusing on their functions, diagnostic and therapeutic applications, and the challenges in their clinical translation. Practical strategies to address these challenges are also discussed, aiming to bridge the gap between EV research and its implementation in healthcareÍtem Significance of PD1 Alternative Splicing in Celiac Disease as a Novel Source for Diagnostic and Therapeutic Target(2021-06) Ponce de León, Candelaria; Lorite, Pedro; López-Casado, Miguel Ángel; Barro, Francisco; Palomeque, Teresa; Torres, María IsabelThis study examines the role of the PD-1/PD-L1 pathway in celiac disease (CD), focusing on its involvement in immune regulation and the impact of altered mRNA splicing on identifying new diagnostic, prognostic, and therapeutic targets. The findings revealed an overexpression of the sPD-1 protein and the PD-1Dex3 transcript in CD. Three novel spliced isoforms were identified: two producing truncated proteins and one encoding a soluble PD-1 variant (sPD-1) due to a loss of exon 3 and part of exon 2. These results suggest that dietary gluten influences cell homeostasis by modulating pre-mRNA splicing of key regulatory proteins, serving as an adaptive response to dietary changes.