Examinando por Autor "Mora, Pablo"
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Ítem A Comparative Analysis of Mitogenomes in Species of the Tapinoma nigerrimum Complex and Other Species of the Genus Tapinoma (Formicidae, Dolichoderinae)(MDPI, 2024-12-02) Ruiz-Mena, Areli; Mora, Pablo; Rico-Porras, José M.; Kaufmann, Bernard; Seifert, Bernhard; Palomeque, Teresa; Lorite, PedroUsing next-generation sequencing data, the complete mitogenomes of six species from the genus Tapinoma were assembled. This study explores the mitochondrial genomes of Tapinoma species, among them the five species from the Tapinoma nigerrimum complex, comparing them with each other and with other species from Dolichoderinae subfamily to understand their evolutionary relationships and evolution. Tapinoma mitochondrial genomes contain the typical set of 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNAs, and the A + T-rich control region. A phylogenetic analysis using the protein-coding gene sequences from available Dolichoderinae mitogenomes supports the monophyletic nature of the genus Tapinoma, with the T. nigerrimum complex forming a well-supported clade. Key findings include genetic traits unique to the T. nigerrimum complex, such as a start codon in the atp8 gene and a complete stop codon in cox1, distinguishing them from other Tapinoma species. Additionally, a gene rearrangement involving tRNA-Trp, tRNA-Cys, and tRNA-Tyr was found exclusively in the Tapinoma species, suggesting a potential phylogenetic marker for the genus.Ítem Complex Evolutionary Histor of Mboumar, a Mariner Element Widely Represented in Ant Genomes(Nature Research, 2020-02) Sanllorente, Olivia; Vela, Jesús; Mora, Pablo; Ruiz-Mena, Areli; Torres, María Isabel; Lorite, Pedro; Palomeque, TeresaThis study examines the mariner-like transposable element Mboumar, previously identified in the ant Messor bouvieri, across 22 ant species from nine subfamilies, including both primitive and derived lineages. The widespread presence of Mboumar-like elements in ant genomes is evident, but the phylogenetic relationships of these elements do not align with the evolutionary history of their ant hosts. Genetic analysis revealed conserved transposable elements with uninterrupted open reading frames in 11 species, encoding transposases closely resembling the active Mboumar-9 transposase. Selection tests indicate purifying selection has shaped the evolution of these elements.Ítem Expression of Elafin and CD200 as Immune Checkpoint Molecules Involved in Celiac Disease.(MDPI, 2024-01) Ponce de León, Candelaria; Lorite, Pedro; López-Casado, Miguel Ángel; Mora, Pablo; Palomeque, Teresa; Torres, María IsabelThis study investigates the role of immune checkpoint molecules in celiac disease (CD), focusing on the CD200/CD200R pathway and Elafin expression and their influence on immune regulation. Limited research exists on these molecules in CD, making these findings significant for understanding its clinical aspects. The results revealed elevated CD200 and CD200R levels and reduced PI3 expression in CD patients compared to healthy controls. CD200 expression, regulated by IFN-gamma, interacts with CD200R to stimulate Th1 and Th17 cytokine production. Specific SNPs, such as rs1733103 and rs41282752, were associated with CD, implicating genetic predisposition. The dysregulation of immune checkpoints in CD contributes to inflammation and autoimmunity, suggesting that therapies targeting these pathways could restore immune balance.Ítem The first insight into Acanthocephalus (Palaeacanthocephala) satellitome: species-specific satellites as potential cytogenetic markers(Springer Nature, 2025-01-23) Marková, Anna; Orosová, Martina; Mora, Pablo; Benovics, Michal; Lorite, PedroAcanthocephalan parasites are often overlooked in many areas of research, and satellitome and cytogenetic analyzes are no exception. The species of the genus Acanthocephalus are known for their very small chromosomes with ambiguous morphology, which makes karyotyping difficult. In this study, we performed the first satellitome analysis of three Acanthocephalus species to identify species- and chromosome-specific satellites that could serve as cytogenetic markers. RepeatExplorer2 revealed a remarkably high number of species-specific repeats, with a predominance of satellite DNAs, alongside variations in repetitive content between sexes. Five satellites in A. anguillae, two in A. lucii and six in A. ranae were successfully mapped to chromosomes using FISH. Each satellite showed a clustered hybridization signal at specific chromosomal locations, which allowed us to create a schematic representation of the distribution of satellites for each species. These newly identified satellites proved to be useful chromosomal markers for the accurate identification of homologous chromosome pairs. No FISH-positive signals were observed on the supernumerary chromosomes of A. anguillae and A. lucii, supporting the hypothesis that these chromosomes have recent origin.