Examinando por Autor "Cobo-Domingo, Justo"
Mostrando 1 - 2 de 2
- Resultados por página
- Opciones de ordenación
Ítem Desarrollo de nuevos híbridos moleculares heterociclo-esteroide y esteroide-[60]fullereno con potencial actividad biológica(Jaén : Universidad de Jaén, 2022-04-28) Almagro-Rodríguez, Luis Enmanuel; Cobo-Domingo, Justo ; Suárez-Navarro, Margarita ; Universidad de Jaén. Departamento de QUÍMICA INORGÁNICA Y ORGÁNICAEn la presente Tesis Doctoral se aborda la obtención de compuestos estructuralmente novedosos y con potencial interés biológico, aplicando la hibridación molecular como herramienta sintética de diseño racional. Para ello, se utiliza como plataforma de conjugación esteroides convenientemente funcionalizados, los que se unen covalentemente a otras moléculas de relevancia química y biológica, como los heterociclos y los fullerenos. Los resultados finales permitieron establecer relaciones sinérgicas de los conjugados evaluados, donde se potencien o modifiquen las propiedades que presentan tanto los esteroides como los heterociclos y el fullereno por separado, siendo interesantes desde el punto de vista farmacológico, en la búsqueda de nuevos agentes antiproliferativos para el tratamiento terapéutico de enfermedades de gran impacto actual como el cáncer.In this doctoral thesis the synthesis of novel compounds with potential biological interest is tackled by the application of molecular hybridization as a synthetic tool in the Fragment Based Drug Design (FBDD). In order to do so, conveniently functionalized steroids are used as starting building blocks which are lately bonded to other relevant chemical entities considered to be biologically privileged, such as heterocycles and fullerenes. The results allowed the establishment of synergic relationships in the conjugates evaluated, where the properties presented by the steroids, heterocycles and fullerene separately are potentiated or modified, being interesting from the pharmacological point of view, in the search for new antiproliferative agents for the therapeutic treatment of diseases of great current impact such as cancer.Ítem The renin-angiotensin system: new insight into old therapies.(BENTHAM SCIENCE PUBL LTD, 2013-04) Ramírez-Sánchez, Manuel; Prieto-Gómez, María Isabel; Wangensteen, Rosemary; Banegas, Inmaculada; Segarra, Ana Belén; Villarejo, Ana Belén; Vives, Francisco; Cobo-Domingo, Justo; de-Gasparo, MarcAlthough the renin-angiotensin system (RAS) is already an old acquaintance, there are often exciting discoveries that improve our knowledge of it and open new therapeutic possibilities. Moreover, well-established drugs, such as angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or beta-blockers, show that their mechanism of action may be the result of parallel pathways other than the ones initially established. A detailed analysis of the RAS can be carried out in part through the study of the enzymes, named angiotensinases, involved in its cascade, whose activity is a reflection of the functionality of their peptide substrates. The study of these enzymes offers the possibility of controlling the effects of angiotensins through various pharmacological manipulations. For example, angiotensinase inhibitors or activators are being used or have been proposed as antihypertensive agents. They have also been suggested as analgesic and antidepressant drugs or targets for drug development against different pathologies such as Alzheimer's disease, epilepsy or ischemia. On the other hand, the analysis of brain asymmetry has revealed surprising results about the laterality of central and peripheral components of the RAS. Such studies indicate that the neurovisceral integration, already proposed by Claude Bernard (1867) should also be analyzed from a bilateral perspective. In this review, the RAS and the role of various angiotensinases implicated in the cascade are revisited. Therapeutic strategies involving some components of the RAS with an unusual vision resulting from a bilateral perspective added to their study are discussed.