DQFA-Artículos
URI permanente para esta colecciónhttps://hdl.handle.net/10953/276
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Examinando DQFA-Artículos por Autor "Alcántara-Durán, Jaime"
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Ítem Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry(Elsevier, 2018-04-25) Alcántara-Durán, Jaime; Moreno-González, David; Gilbert-López, Bienvenida; Molina-Díaz, Antonio; García-Reyes, Juan F.In this work, a sensitive method based on nanoflow liquid chromatography high-resolution mass spectrometry has been developed for the multiresidue determination of veterinary drugs residues in honey, veal muscle, egg and milk. Salting-out supported liquid extraction was employed as sample treatment for milk, veal muscle and egg, while a modified QuEChERS procedure was used in honey. The enhancement of sensitivity provided by the nanoflow LC system also allowed the implementation of high dilution factors as high as 100:1. For all matrices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus, the use of external standard calibration instead of matrix-matched calibration of each sample, and the subsequent increase of laboratory throughput. At spiked levels as low as 0.1 or 1 µg kg−1 before the 1:100 dilution, the obtained signals were still significantly higher than the instrumental limit of quantitation (S/N 10).Ítem Multi-residue pesticide analysis in virgin olive oil by nanoflow liquid chromatography high resolution mass spectrometry(Elsevier, 2018-08-10) Moreno-González, David; Alcántara-Durán, Jaime; Addona, Silvina M.; Beneito-Cambra, MiriamIn this article, a nanoflow liquid chromatography system coupled to high resolution mass spectrometry (nanoflow LC/ESI Q-Orbitrap-MS) has been applied for the development of a multiresidue pesticide method for the determination of 162 multiclass pesticides in olive oil samples. Due to the relatively high lipid content of the raw QuEChERS acetonitrile extracts obtained from this type of fatty vegetable samples, a dispersive solid phase extraction (dSPE) sorbent proposed to retain both fatty acids and triglycerides, namely Enhanced Matrix Removal-Lipid (EMR-Lipid) has been implemented as additional cleanup step. The analytical performances of the proposed method were evaluated,achieving recoveries in the range 75–119% with relative standard deviations lower than 19% (n = 6). The dSPE sorbent allowed the removal of most coextracted interferences without a significant loss of analytes. Matrix effects were also evaluated, showing a negligible effect for most of the compounds tested, when a dilution factor of 50 was applied. Notably, despite the use of relatively high dilution factors (e.g. 1:50) to minimize matrix effects, the lowest concentration levels detected with this method – in the low μg kg−1 range – are well below the corresponding maximum residue levels established by the current European legislation