Alcántara-Durán, JaimeMoreno-González, DavidGilbert-López, BienvenidaMolina-Díaz, AntonioGarcía-Reyes, Juan F.2024-09-262024-09-262018-04-251873-707210.1016/j.foodchem.2017.10.083https://www.sciencedirect.com/science/article/pii/S0308814617317211https://hdl.handle.net/10953/3244In this work, a sensitive method based on nanoflow liquid chromatography high-resolution mass spectrometry has been developed for the multiresidue determination of veterinary drugs residues in honey, veal muscle, egg and milk. Salting-out supported liquid extraction was employed as sample treatment for milk, veal muscle and egg, while a modified QuEChERS procedure was used in honey. The enhancement of sensitivity provided by the nanoflow LC system also allowed the implementation of high dilution factors as high as 100:1. For all matrices tested, matrix effects were negligible starting from a dilution factor of 100, enabling, thus, the use of external standard calibration instead of matrix-matched calibration of each sample, and the subsequent increase of laboratory throughput. At spiked levels as low as 0.1 or 1 µg kg−1 before the 1:100 dilution, the obtained signals were still significantly higher than the instrumental limit of quantitation (S/N 10).engCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/nanoflow liquid chromatography;mass spectrometry high resolutionveterinary drugs;matrix effect info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess