Sánchez-León, SusanaGiménez-Alvear, María JoséComino-Montilla, IsabelSousa, CarolinaLópez-Casado, Miguel ÁngelTorres-López, María IsabelBarro, Francisco2025-01-172025-01-172019-12Sánchez-León S, Giménez MJ, Comino I, et al. Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition. Nutrients. 2019;11(12):29332072-664310.3390/nu11122933https://www.mdpi.com/2072-6643/11/12/2933https://hdl.handle.net/10953/4037En pro de mi compromiso con la difusión de la ciencia, este artículo se encuentra depositado, siguiendo las normas establecidas por la editorial de la revista, en el repositorio de la Universidad de Jaén (RUJA) con su identificador persistenteGluten proteins in wheat are essential for bread-making but are also responsible for triggering gastrointestinal disorders such as celiac disease (CD), which affects approximately 1% of the Western population. Currently, the only effective treatment is a strict gluten-free diet. This study explores the use of RNA interference (RNAi) to reduce the expression of genes encoding immunogenic gluten proteins, offering a potential solution for developing CD-compatible cereals. These findings highlight the potential of RNAi technology to produce wheat varieties that are less immunogenic for CD patients while retaining some functional properties.engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/PBMCsRNAiCeliac diseaseLow-gluten wheatinfo:eu-repo/semantics/article6 Ciencias aplicadas. Medicina. Tecnología.info:eu-repo/semantics/openAccess