Contreras-Gámez, María del MarGalán-Martín, ÁngelSeixas, Nalinda Costa Lopes, André M.Silvestre, ArmandoCastro, Eulogio2025-02-062025-02-062022-11-260960852410.1016/j.biortech.2022.128396https://hdl.handle.net/10953/4659Pretreatment processes — recognized as critical steps for efficient biomass refining — have received much attention over the last two decades. In this context, deep eutectic solvents (DES) have emerged as a novel alternative to conventional solvents representing a step forward in achieving more sustainable processes with both environmental and economic benefits. This paper presents an updated review of the state-of-the-art of DES-based applications in biorefinery schemes. Besides describing the fundamentals of DES composition, synthesis, and recycling, this study presents a comprehensive review of existing techno-economic and life cycle assessment studies. Challenges, barriers, and perspectives for the scale-up of DES-based processes are also discussed.engBiorefineryDeep eutectic solventsPretreatmentTechno-economic assessmentLife Cycle Assessmentinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess